Sensor-fouling, optical-interference, and separation-selectivity constraints, and how the extracorporeal design addresses each.
| Limitation of conventional approach | Resolved? | Rationale in Hemocorr |
|---|---|---|
| Platelet activation on sensor surface | Yes | Platelet-free plasma |
| Cellular adhesion & thrombus formation | Yes | Cell-free plasma |
| Dynamic protein adhesion / fouling | Minimized | Molecular fractionation |
| Need for anti-fouling polymer coatings | Minimized | Fractionation reduces protein load |
| Heparin & heparin-related adverse effects | Removed | Reversible chemical anti-coagulation |
| Sensor drift & frequent recalibration | Minimized | Cell-free, fractionated, controlled environment |
| Interstitial time-lag of 4–10 minutes | Removed | Direct measurement on plasma |
| Poor tissue penetration of mid-IR light | Yes | Extracorporeal — no tissue in the path |
| Tissue interference & spectral overlap | Yes | Extracorporeal + fractionation |
| Need for special algorithms to negate interference | Yes | Interference removed at source |
| NIR site-specificity (finger, earlobe, lip…) | Yes | Single controlled measurement site |
| Interference by blood pigment proteins | Yes | Cell-free plasma + fractionation |
| Restricted wavelength choice | Yes | Cell-free plasma + fractionation |
| UV absorbance by DNA & proteins | Yes | Cell-free plasma + fractionation |
| Visible-light absorbance by haemoglobin | Yes | Cell-free plasma |
| Optical polarimetry scattering by skin | Yes | Extracorporeal system |
| Polarimetry: corneal birefringence with motion | Yes | Extracorporeal system |
| Polarimetry: Vit-C & albumin interference | Minimized | Plasma fractionation |
| Interference from cloudy media | Minimized | Plasma fractionation |
| Raman: tissue masking & background noise | Yes | Extracorporeal system |
| Raman: skin tone / thickness / hydration variance | Yes | Extracorporeal system |
| OCT: dermal interference | Yes | Extracorporeal system |
| Microwave: tissue dielectric interference | Yes | Extracorporeal system |
| Dialysis removes non-target molecules by size | Yes | Target-specific capture, not size filtration |
| Adsorption columns bind non-specifically | Yes | Selective capture in simplified fraction |
| Removal rate & extent can't be controlled | Yes | Dose calculated from real-time concentration |
| No real-time feedback on the correction itself | Yes | Re-measurement after capture confirms set-point |